The bicarbonate/carbon dioxide pair increases hydrogen peroxide-mediated hyperoxidation of human peroxiredoxin 1.

ABSTRACT: 2-Cys peroxiredoxins (Prxs) rapidly reduce H₂O₂, thereby acting as antioxidants and also as sensors and transmitters of H₂O₂ signals in cells. Interestingly, eukaryotic 2-Cys Prxs lose their peroxidase activity at high H₂O₂ levels. Under these conditions, H₂O₂ oxidizes the sulfenic acid derivative of the Prx peroxidatic Cys (C_PSOH) to the sulfinate (C_PSO₂ ^-) and sulfonated (C_PSO₃ ^-) forms, redirecting the C_PSOH intermediate from the catalytic cycle to the hyperoxidation/inactivation pathway. The susceptibility of 2-Cys Prxs to hyperoxidation varies greatly and depends on structural features that affect the lifetime o

SUBMITTER: Truzzi DR 

PROVIDER: S-EPMC6755790 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature