Differences in gut microbiome composition between persons with chronic schizophrenia and healthy comparison subjects.

ABSTRACT: Intestinal microbiome and gut-brain axis have been receiving increasing attention for their role in the regulation of brain/behavior and possible biological basis of psychiatric disorders. Several recent clinical studies have linked the microbiome with neuropsychiatric conditions, although the literature on schizophrenia is quite limited. This study investigated gut microbiome composition in 50 individuals, including 25 persons with chronic schizophrenia and 25 demographically-matched non-psychiatric comparison subjects (NCs). Stool samples were collected and assayed using 16S rRNA sequencing of the V4 region. Examination of unweighted UniFrac and Bray-Curtis dissimilarity revealed significant community-level separation in microbiome composition between the two subject groups. At the phylu

SUBMITTER: Nguyen TT 

PROVIDER: S-EPMC6755901 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature