Twins with different personalities: STAT5B-but not STAT5A-has a key role in BCR/ABL-induced leukemia.

ABSTRACT: Deregulation of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway is found in cancer with STAT5A/B controlling leukemic cell survival and disease progression. As mutations in STAT5B, but not STAT5A, have been frequently described in hematopoietic tumors, we used BCR/ABL as model systems to investigate the contribution of STAT5A or STAT5B for leukemogenesis. The absence of STAT5A decreased cell survival and colony formation. Even more drastic effects were observed in the absence of STAT5B. STAT5B-deficient cells formed BCR/ABL⁺ colonies or stable cell lines at low frequency. The rarely evolving Stat5b^-/- cell lines expressed enhanced levels of BCR/ABL oncoprotein compared to wild-type cells. In line, Stat5b^-/- l

SUBMITTER: Kollmann S 

PROVIDER: S-EPMC6755975 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature