TRiC/CCT chaperonins are essential for organ growth by interacting with insulin/TOR signaling in Drosophila.

ABSTRACT: Organ size is regulated by intercellular signaling for cell growth and proliferation. The TOR pathway mediates a key signaling mechanism for controlling cell size and number in organ growth. Chaperonin containing TCP-1 (CCT) is a complex that assists protein folding and function, but its role in animal development is largely unknown. Here we show that the CCT complex is required for organ growth by interacting with the TOR pathway in Drosophila. Reduction of CCT4 results in growth defects by affecting both cell size and proliferation. Loss of CCT4 causes preferential cell death anterior to the morphogenetic furrow in the eye disc and within wing pouch in the wing disc. Depletion of any CCT subunit in the eye disc results in headless phenotype. Overgrowth by active TOR signaling is suppress

SUBMITTER: Kim AR 

PROVIDER: S-EPMC6756063 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature