Particulate Air Pollutants and Trajectories of Depressive Symptoms in Older Women.

ABSTRACT:

Objectives

Although several environmental factors contribute to the etiology of late-life depressive symptoms, the role of ambient air pollution has been understudied. Experimental data support the neurotoxicity of airborne particulate matter with aerodynamic diameter of ≤2.5 μm (PM_2.5), but it remains unclear whether long-term exposure is associated with late-life depressive symptoms. Our secondary aim was to explore whether the observed associations between exposure and depressive symptoms are explained by dementia risk.

Design, setting, and participants

Prospective community-dwelling cohort study from the Women's Health Initiative Study of Cognitive Aging (1999-2010). Our analyses included 1,989 older women (baseline age 73.3 ± 3.75) with no prior depression or

SUBMITTER: Petkus AJ 

PROVIDER: S-EPMC6756168 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature