Sex Differences in Circulating Biomarkers of Cardiovascular Disease.

ABSTRACT:

Background

Differences in proteomic profiles between men and women may provide insights into the biological pathways that contribute to known sex differences in cardiovascular disease (CVD).

Objectives

This study sought to investigate sex differences in circulating biomarkers representative of biological pathways implicated in the development of CVD among Framingham Heart Study participants.

Methods

The authors measured 71 circulating CVD protein biomarkers in 7,184 participants (54% women, mean age 49 years). Multivariable models were used to evaluate the associations of sex, menopause, and hormone status with biomarkers. Cox models were used to examine whether sex modified the association of biomarkers with incident CVD.

Results

Of 71 biomarkers examined, 61

SUBMITTER: Lau ES 

PROVIDER: S-EPMC6756178 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature