Neurotensin and its receptors mediate neuroendocrine transdifferentiation in prostate cancer.

ABSTRACT: Castration-resistant prostate cancer (CRPC) with neuroendocrine differentiation (NED) is a lethal disease for which effective therapies are urgently needed. The mechanism underlying development of CRPC with NED, however, remains largely uncharacterized. In this study, we explored and characterized the functional role of neurotensin (NTS) in cell line and animal models of CRPC with NED. NTS was acutely induced by androgen deprivation in animal models of prostate cancer (PCa) and activated downstream signaling leading to NED through activation of neurotensin receptor 1 (NTSR1) and neurotensin receptor 3 (NTSR3), but not neurotensin receptor 2 (NTSR2). Our findings also revealed the existence of a CK8⁺/CK14⁺ subpopulation in the LNCaP cell line that expresses high levels

SUBMITTER: Zhu S 

PROVIDER: S-EPMC6756221 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature