Tranexamic acid in cardiac surgery: a systematic review and meta-analysis (protocol).

ABSTRACT:

Introduction

Bleeding during cardiac surgery is associated with increased morbidity and mortality. Tranexamic acid is an antifibrinolytic with proven efficacy in major surgeries. Current clinical practice guidelines recommend intraoperative use in cardiac procedures. However, several complications have been reported with tranexamic acid including seizures. This review intends to summarise the evidence examining the efficacy and safety of tranexamic acid in patients undergoing cardiac surgery.

Methods/design

We will search MEDLINE, Embase, PubMED, ACPJC, CINAHL and the Cochrane trial registry for eligible randomised controlled trials, the search dates for all databases will be from inception until 1 January 2019, investigating the perioperative use of topical and/or intraveno

SUBMITTER: Alaifan T 

PROVIDER: S-EPMC6756438 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature