Skin Protein Profile after Major Weight Loss and Its Role in Body Contouring Surgery.

ABSTRACT: Chronic inflammation during morbid obesity significantly alters cutaneous tissue. Large weight loss achieved after bariatric surgery minimizes or halts damage caused by metabolic syndrome, but further deteriorates the clinical condition of skin. Postbariatric skin flaccidity produces major difficulties to plastic surgery. In this study, we analyzed differences in protein composition of the skin between patients with morbid obesity and those after large weight loss and established correlations between differentially expressed proteins and clinical characteristics of postbariatric skin tissue, to improve body contouring surgery techniques.

Methods

Skin fragments were removed from the abdomen of 32 patients, who were allocated into 3 groups: morbidly obese, large weight loss without su

SUBMITTER: Gallo JRB 

PROVIDER: S-EPMC6756662 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature