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Cannabis Use: Neurobiological, Behavioral, and Sex/Gender Considerations.

ABSTRACT:

Purpose of review

To summarize the current literature on the effects of cannabinoids in humans and to discuss the existing literature on the sex- and gender-related differences in the effects of cannabinoids.

Recent findings

Cannabis and its constituent cannabinoids are associated with risk of addiction, cognitive deficits and mood/psychotic disorders. Preclinical and emerging clinical data suggest greater sensitivity to the effects of cannabinoids in women.

Summary

Cannabis is one of the most commonly used drugs with increasing rates of use. Women in particular may be at a greater risk of adverse outcomes given the previously described "telescoping effect" of substance use in women. Human data examining the sex- and gender-related differences in the effects of cannabinoids and factors underlying these differences are very limited. This represents a critical gap in the literature and needs to be systematically examined in future studies.

SUBMITTER: Nia AB

PROVIDER: S-EPMC6756752 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Cannabis Use: Neurobiological, Behavioral, and Sex/Gender Considerations.

Nia Anahita Bassir AB Mann Claire C Kaur Harsimar H Ranganathan Mohini M

Current behavioral neuroscience reports 20181110 4

<h4>Purpose of review</h4>To summarize the current literature on the effects of cannabinoids in humans and to discuss the existing literature on the sex- and gender-related differences in the effects of cannabinoids.<h4>Recent findings</h4>Cannabis and its constituent cannabinoids are associated with risk of addiction, cognitive deficits and mood/psychotic disorders. Preclinical and emerging clinical data suggest greater sensitivity to the effects of cannabinoids in women.<h4>Summary</h4>Cannabi ...[more]

PMID: 31548918

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