New insights into the genomic landscape of meningiomas identified FGFR3 in a subset of patients with favorable prognoses.

ABSTRACT: Background: With a prevalence of 170 000 adults in the US alone, meningiomas are the most common primary intracranial tumors. The management of skull base meningiomas is challenging due to their complexity and proximity to crucial nearby structures. The identification of oncogenic mutations has provided further insights into the tumorigenesis of meningioma and the possibility of targeted therapy. This study aimed to further investigate the association of mutational profiles with anatomical distribution, histological subtype, WHO grade, and recurrence in patients with meningioma. Methods: Tissue samples were collected from 71 patients diagnosed with meningioma from 2008 to 2016. A total of 51 cases were skull based. Samples were subjected to targeted sequencing using a next ge

SUBMITTER: AlSahlawi A 

PROVIDER: S-EPMC6756861 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature