Hypertonic Mannitol for the Prevention of Intradialytic Hypotension: A Randomized Controlled Trial.

ABSTRACT:

Rationale & objective

Intradialytic hypotension (IDH) is a common complication at the initiation of hemodialysis (HD) therapy, is associated with greater mortality, and may be related to relatively rapid shifts in plasma osmolality. This study sought to evaluate the effect of an intervention to minimize intradialytic changes in plasma osmolality on the occurrence of IDH.

Study design

Double-blind, single-center, randomized, controlled trial.

Setting & participants

Individuals requiring initiation of HD for acute or chronic kidney disease.

Intervention

Mannitol, 0.25g/kg/h, versus a similar volume of 0.9% saline solution during the first 3 HD sessions.

Outcomes

The primary end point was average decline in systolic blood pressure (SBP). The secondary end p

SUBMITTER: Mc Causland FR 

PROVIDER: S-EPMC6756938 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature