Brain Connectivity Measures Improve Modeling of Functional Outcome After Acute Ischemic Stroke.

ABSTRACT: Background and Purpose- The ability to model long-term functional outcomes after acute ischemic stroke represents a major clinical challenge. One approach to potentially improve prediction modeling involves the analysis of connectomics. The field of connectomics represents the brain's connectivity as a graph, whose topological properties have helped uncover underlying mechanisms of brain function in health and disease. Specifically, we assessed the impact of stroke lesions on rich club organization, a high capacity backbone system of brain function. Methods- In a hospital-based cohort of 41 acute ischemic stroke patients, we investigated the effect of acute infarcts on the brain's prestroke rich club backbone and poststroke functional connectomes with respect to poststroke outcome. Functio

SUBMITTER: Ktena SI 

PROVIDER: S-EPMC6756947 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature