Cord Leptin is Associated with Neuropsychomotor Development in Childhood.

ABSTRACT: OBJECTIVE:Leptin is critical for central nervous system development and maturation. This study aimed to evaluate the potential regulatory role of cord leptin in the neuropsychomotor development of children ages 18 months to 6 years. METHODS:This study included 424 children from a prospective mother-child cohort (Rhea Study; Crete, Greece) with available cord leptin levels and data on neurodevelopmental outcomes at 18 months (Bayley Scales of Infant and Toddler Development, Third Edition), 4 years (McCarthy Scales of Children's Abilities), and 6 years (Raven's Coloured Progressive Matrices and Trail Making Test). Multivariable linear regression models were used to explore the associations. RESULTS:Each 10-ng/mL increase in the cord leptin level was associated with increased scores on the gr

SUBMITTER: Karakosta P 

PROVIDER: S-EPMC6756960 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature