Gene Expression Signatures Associated With Survival Times of Pediatric Patients With Biliary Atresia Identify Potential Therapeutic Agents.

ABSTRACT:

Background & aims

Little is known about the factors that affect outcomes of patients with biliary atresia and there are no medical therapies that increase biliary drainage.

Methods

Liver biopsies and clinical data were obtained from infants with cholestasis and from children without liver disease (controls); messenger RNA (mRNA) was isolated, randomly assigned to discovery (n = 121) and validation sets (n = 50), and analyzed by RNA sequencing. Using the Superpc R package followed by Cox regression analysis, we sought to identify gene expression profiles that correlated with survival without liver transplantation at 24 months of age. We also searched for combinations of gene expression patterns, clinical factors, and laboratory results obtained at diagnosis and at 1 and 3 mon

SUBMITTER: Luo Z 

PROVIDER: S-EPMC6756963 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature