Expression profiles of circular RNAs in human colorectal cancer based on RNA deep sequencing.

ABSTRACT:

Background

Circular RNAs (circRNAs) are a novel group of RNAs and play essential roles in cancers. However, the expression profiles of circRNAs in human colorectal cancer (CRC) are largely unclear.

Methods

The differentially expressed circRNAs, mRNAs, and microRNAs (miRNAs) between CRC tissues and paired adjacent normal tissues were first screened. Then, gene ontology and pathway analyses were performed to predict the possible functions. In addition, we identified the differentially expressed circRNAs in CRC correlated with Krüppel-like factor 4 (KLF4) and validated their expression levels in CRC tissues. Finally, the correlations between hsa_circ_0142527 expression levels and clinicopathological features of patients with CRC were also analyzed.

Results

After filtered

SUBMITTER: Ge J 

PROVIDER: S-EPMC6757124 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature