Association between epigenetic age acceleration and depressive symptoms in a prospective cohort study of urban-dwelling adults.

ABSTRACT:

Objective

This study tests associations of DNA methylation-based (DNAm) measures of epigenetic age acceleration (EAA) with cross-sectional and longitudinal depressive symptoms in an urban sample of middle-aged adults.

Methods

White and African-American adult participants in the Healthy Aging in Neighborhoods of Diversity across the Life Span study for whom DNA samples were analyzed (baseline age: 30-65 years) we included. We estimated three DNAm based EAA measures: (1) universal epigenetic age acceleration (AgeAccel); (2) intrinsic epigenetic age acceleration (IEAA); and (3) extrinsic epigenetic age acceleration (EEAA). Depressive symptoms were assessed using the 20-item Center for Epidemiological Studies-Depression scale total and sub-domain scores at baseline (2004-2009) a

SUBMITTER: Beydoun MA 

PROVIDER: S-EPMC6757325 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature