Localised grey matter atrophy in multiple sclerosis is network-based: a coordinate-based meta-analysis.

ABSTRACT:

Aim

To test the network degeneration hypothesis in multiple sclerosis (MS) with a two-stage coordinate-based meta-analysis by: (1) characterising regional selectivity of grey matter (GM) atrophy and (2) testing for functional connectivity involving these regions.

Materials and methods

Meta-analytic sources included 33 journal articles (1,666 MS patients and 1,269 healthy controls) with coordinate-based results from voxel-based morphometry analysis demonstrating GM atrophy. Mass univariate and multivariate coordinate-based meta-analyses were performed to identify a convergent pattern of GM atrophy and determine inter-regional co-activation (as a surrogate of functional connectivity), with anatomical likelihood estimation and functional meta-analytic connectivity modelling, re

SUBMITTER: Chiang FL 

PROVIDER: S-EPMC6757337 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature