Atypical microglial response to biodiesel exhaust in healthy and hypertensive rats.

ABSTRACT: Accumulating evidence suggests a deleterious role for urban air pollution in central nervous system (CNS) diseases and neurodevelopmental disorders. Microglia, the resident innate immune cells and sentinels in the brain, are a common source of neuroinflammation and are implicated in air pollution-induced CNS effects. While renewable energy, such as soy-based biofuel, is of increasing public interest, there is little information on how soy biofuel may affect the brain, especially in people with preexisting disease conditions. To address this, male spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto (WKY) rats were exposed to 100% Soy-based Biodiesel Exhaust (100SBDE; 0, 50, 150 and 500μg/m³) by inhalation, 4h/day for 4 weeks (5 days/week). Ionized calcium-binding

SUBMITTER: Mumaw CL 

PROVIDER: S-EPMC6757344 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature