A novel construct with biomechanical flexibility for articular cartilage regeneration.

ABSTRACT: BACKGROUND:Although tissue-engineered cartilage has been broadly studied, complete integration of regenerated cartilage with residual cartilage is still difficult for the inferior mechanical and biochemical feature of neocartilage. Chondrogenesis of mesenchymal stem cells can be induced by biophysical and biochemical factors. METHODS:In this study, autologous platelet-rich fibrin (PRF) membrane was used as a growth factor-rich scaffold that may facilitate differentiation of the transplanted bone marrow mesenchymal stem cells (BMSCs). At the same time, hydrostatic pressure was adopted for pre-adjustment of the seed cells before transplantation that may promote the mechanical flexibility of neocartilage. RESULTS:An in vitro study showed that the feasible hydrostatic pressure stimulation subs

SUBMITTER: Cheng B 

PROVIDER: S-EPMC6757433 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature