Label-free quantitative proteomic analysis of molting-related proteins of Trichinella spiralis intestinal infective larvae.

ABSTRACT: Molting is a key step for body-size expansion and environmental adaptation of parasitic nematodes, and it is extremely important for Trichinella spiralis growth and development, but the molting mechanism is not fully understood. In this work, label-free LC-MS/MS was used to determine the proteome differences between T. spiralis muscle larvae (ML) at the encapsulated stage and intestinal infective larvae (IIL) at the molting stage. The results showed that a total of 2885 T. spiralis proteins were identified, 323 of which were differentially expressed. These proteins were involved in cuticle structural elements, regulation of cuticle synthesis, remodeling and degradation, and hormonal regulation of molting. These differential proteins were also involved in diverse intracellular pathways, suc

SUBMITTER: Ren HN 

PROVIDER: S-EPMC6757440 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature