Canine ovarian gonadoblastoma with dysgerminoma overgrowth: a case study and literature review.

ABSTRACT:

Background

Gonadoblastoma (GB) is a rare mixed germ cell-sex cord-stromal tumour, first described in humans, commonly found in dysgenetic gonads of intersex patients that have a Y chromosome. However, this entity in not recognized in the WHO classification of tumours of genital system of domestic animals. Herein, we describe a case of ovarian gonadoblastoma with proliferation of dysgerminoma and sex cord-stromal tumour components, in a phenotypically and cytogenetically normal bitch.

Case presentation

A 17-year-old cross-breed bitch had a firm, grey-white multinodular mass in the left ovary. The tumour was submitted to histopathological examination and Y chromosome detected through karyotype analysis and PCR studies. Microscopically, the ovary was almost replaced by an irreg

SUBMITTER: Flores AR 

PROVIDER: S-EPMC6757443 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature