Parental non-alcoholic fatty liver disease increases risk of non-alcoholic fatty liver disease in offspring.

ABSTRACT:

Background & aims

Little is known regarding the risk of hepatic steatosis (HS) among adult children of affected parents. We examined the association between parental and offspring HS in the multigenerational Framingham Heart Study, which characterized HS using computed tomography.

Methods

We performed multivariable logistic regression models adjusted for age, sex, alcohol use, and body mass index to generate the odds of HS according to parental HS. We determined the proportion of participants with HS according to parental HS and the presence or absence of hypertension, diabetes, or obesity (BMI ≥30 kg/m² ). After excluding heavy alcohol use (n = 126) and missing covariates (n = 1), 785 offspring with at least one parent were included.

Results

Approximately

SUBMITTER: Long MT 

PROVIDER: S-EPMC6758911 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature