Ancient Hybridization and Adaptive Introgression of an Invadolysin Gene in Schistosome Parasites.

ABSTRACT: Introgression among parasite species has the potential to transfer traits of biomedical importance across species boundaries. The parasitic blood fluke Schistosoma haematobium causes urogenital schistosomiasis in humans across sub-Saharan Africa. Hybridization with other schistosome species is assumed to occur commonly, because genetic crosses between S. haematobium and livestock schistosomes, including S. bovis, can be staged in the laboratory, and sequencing of mtDNA and rDNA amplified from microscopic miracidia larvae frequently reveals markers from different species. However, the frequency, direction, age, and genomic consequences of hybridization are unknown. We hatched miracidia from eggs and sequenced the exomes from 96 individual S. haematobium miracidia from infected patients from

SUBMITTER: Platt RN 

PROVIDER: S-EPMC6759076 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature