Selective and Sensocompatible Electrochemical Nitric Oxide Sensor with a Bilaminar Design.

ABSTRACT: Macrophages mediate mammalian inflammation in part by the release of the gasotransmitter, nitric oxide (NO). Electrochemical methods represent the best means of direct, continuous measurement of NO, but monitoring continuous release from immunostimulated macrophages remains analytically challenging. Long release durations necessitate consistent sensor performance (i.e., sensitivity and selectivity for NO) in proteinaceous media. Herein, we describe the fabrication of an electrochemical sensor modified by an electropolymerized 5-amino-1-naphthol (poly(5A1N)) film in conjunction with a fluorinated xerogel topcoat. The unique combination of these membranes ensures selective detection of NO that is maintained over extended periods of use (>24 h) in biological media without performance deterior

SUBMITTER: Brown MD 

PROVIDER: S-EPMC6759084 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature