Relationship between T-cell receptor α gene polymorphisms and symptomatic differences in patients with narcolepsy type 1.

ABSTRACT:

Background

Recent genome-wide association studies have identified an important role of T-cell receptor α (TRA) gene in the development of narcolepsy type 1. However, the role of TRA haplotype polymorphisms in the symptomatic diversity of narcolepsy remains unclear. This study aimed to investigate whether TRA polymorphisms can influence the symptomatic diversity of narcolepsy.

Methods

Totally, 903 patients with narcolepsy type 1 were included in the study. Patients were divided into different groups according to their symptoms. First, 13 genotyped single nucleotide polymorphisms in the TRA were assessed for their association with symptoms of narcolepsy. We used the Chi-square test to determine differences in genotype frequencies in patients with narcolepsy. Further, we identi

SUBMITTER: Ouyang H 

PROVIDER: S-EPMC6759118 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature