V1 interneurons regulate the pattern and frequency of locomotor-like activity in the neonatal mouse spinal cord.

ABSTRACT: In the mouse spinal cord, V1 interneurons are a heterogeneous population of inhibitory spinal interneurons that have been implicated in regulating the frequency of the locomotor rhythm and in organizing flexor and extensor alternation. By introducing archaerhodopsin into engrailed-1-positive neurons, we demonstrate that the function of V1 neurons in locomotor-like activity is more complex than previously thought. In the whole cord, V1 hyperpolarization increased the rhythmic synaptic drive to flexor and extensor motoneurons, increased the spiking in each cycle, and slowed the locomotor-like rhythm. In the hemicord, V1 hyperpolarization accelerated the rhythm after an initial period of tonic activity, implying that a subset of V1 neurons are active in the hemicord, which was confirmed by ca

SUBMITTER: Falgairolle M 

PROVIDER: S-EPMC6759197 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature