Joint effects of environmental exposures and familial susceptibility to lung cancer in Chinese never smoking men and women.

ABSTRACT:

Objectives

Previous epidemiological studies had limited power to investigate the joint effects of individual environmental risk factors and familial susceptibility to lung cancer. This study aimed to address this shortcoming.

Methods

We recruited 345 never smoking lung cancer cases and 828 community referents. We developed a collective environmental exposure index by assigning a value of 1 to subjects at high risks regarding environmental risk factors and 0 otherwise, and then summed over using weights equivalent to the excess odds ratio. Potential additive and multiplicative interactions between environmental exposure index and family cancer history were examined.

Results

Compared with "low environmental exposure and without family cancer history", the odds ratio was

SUBMITTER: Tse LA 

PROVIDER: S-EPMC6759229 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature