Composite-Scattering Plasmonic Nanoprobes for Label-Free, Quantitative Biomolecular Sensing.

ABSTRACT: Biosensing based on localized surface plasmon resonance (LSPR) relies on concentrating light to a nanometeric spot and leads to a highly enhanced electromagnetic field near the metal nanostructure. Here, a design of plasmonic nanostructures based on rationally structured metal-dielectric combinations is presented, called composite scattering probes (CSPs), to generate an integrated multimodal biosensing platform featuring LSPR and surface-enhanced Raman spectroscopy (SERS). Specifically, CSP configurations are proposed, which have several prominent resonance peaks enabling higher tunability and sensitivity for self-referenced multiplexed analyte sensing. Using electron-beam evaporation and thermal dewetting, large-area, uniform, and tunable CSPs are fabricated, which are suitable for label

SUBMITTER: Zhang C 

PROVIDER: S-EPMC6759334 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature