Influence of hepatic steatosis on the outcomes of patients with chronic hepatitis B treated with entecavir and tenofovir.

ABSTRACT:

Background/aims

The influence of hepatic steatosis (HS) on chronic hepatitis B (CHB) is unclear. We evaluated the influence of the degree of HS, assessed using the controlled attenuation parameter (CAP) of transient elastography (TE), on treatment outcomes in CHB patients initiated on antiviral therapy.

Methods

A total of 334 patients who were initiated on entecavir or tenofovir between 2007 and 2016 with available TE results were recruited.

Results

Of the total study population, 146 (43.7%) patients had HS (CAP > 238 dB/m). Three-hundred-three patients (90.7%) achieved complete virological response (CVR) (hepatitis B virus DNA<12 IU/L), and 25 patients (7.5%) developed hepatocellular carcinoma (HCC). Among hepatitis B e antigen (HBeAg)-positive patients (n=172, 51.5%

SUBMITTER: Kim DS 

PROVIDER: S-EPMC6759433 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature