Prognostic Roles of Central Carbon Metabolism-Associated Genes in Patients With Low-Grade Glioma.

ABSTRACT: Purpose: Metabolic alterations are crucial for tumor progression and response to therapy. The comprehensive model of combined central carbon metabolism-associated genes that contribute to the outcomes of glioma and astrocytoma is not well understood. Method: We studied the profiles of 63 genes involved in central carbon metabolism in 514 relatively low-grade glioma patients. The different distributions of gene expression in gliomas and astrocytoma were identified. The differential gene expression between each cohort and the correlations with prognosis were detected. Finally, we built a tentative model to detect the prognostic roles of carbon metabolism-associated genes in astrocytoma. Result: Two primary clusters and four subclusters with significantly different overal

SUBMITTER: Wang L 

PROVIDER: S-EPMC6759923 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature