Ontology highlight
ABSTRACT:
SUBMITTER: Tabassum R
PROVIDER: S-EPMC6760179 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Nature communications 20190924 1
Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome-wide association analyses of 141 lipid species (n = 2,181 individuals), followed by phenome-wide scans with 25 CVD related phenotypes (n = 511,700 individuals). We identify 35 lipid-species-associated loci (P <5 ×10<sup>-8</sup>), 10 of which associate with CVD risk including five new loci-COL5A1, GLTPD2, SPTLC3, MBOAT7 ...[more]