Dataset Information

In Silico and In Vivo Studies Detect Functional Repair Mechanisms in a Volumetric Muscle Loss Injury.

ABSTRACT:

Impact statement

Despite medical advances, volumetric muscle loss (VML) injuries to craniofacial muscles represent an unmet clinical need. We report an implantable tissue-engineered construct that leads to substantial tissue regeneration and functional recovery in a preclinical model of VML injury that is dimensionally relevant to unilateral cleft lip repair, and a series of corresponding computational models that provide biomechanical insight into mechanism(s) responsible for the VML-induced functional deficits and recovery following tissue-engineered muscle repair implantation. This unique combined approach represents a critical first step toward establishing a crucial biomechanical basis for the development of efficacious regenerative technologies, considering the spectrum of VML injuries.

SUBMITTER: Passipieri JA

PROVIDER: S-EPMC6760186 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Publications

<i>In Silico</i> and <i>In Vivo</i> Studies Detect Functional Repair Mechanisms in a Volumetric Muscle Loss Injury.

Passipieri Juliana A JA Hu Xiao X Mintz Ellen E Dienes Jack J Baker Hannah B HB Wallace C Hunter CH Blemker Silvia S SS Christ George J GJ

Tissue engineering. Part A 20190318 17-18

<h4>Impact statement</h4>Despite medical advances, volumetric muscle loss (VML) injuries to craniofacial muscles represent an unmet clinical need. We report an implantable tissue-engineered construct that leads to substantial tissue regeneration and functional recovery in a preclinical model of VML injury that is dimensionally relevant to unilateral cleft lip repair, and a series of corresponding computational models that provide biomechanical insight into mechanism(s) responsible for the VML-in ...[more]

PMID: 30882277

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