Cancer Immunotherapy with T Cells Carrying Bispecific Receptors That Mimic Antibodies.

ABSTRACT: Tumors are inherently heterogeneous in antigen expression, and escape from immune surveillance due to antigen loss remains one of the limitations of targeted immunotherapy. Despite the clinical use of adoptive therapy with chimeric antigen receptor (CAR)-redirected T cells in lymphoblastic leukemia, treatment failure due to epitope loss occurs. Targeting multiple tumor-associated antigens (TAAs) may thus improve the outcome of CAR-T cell therapies. CARs developed to simultaneously target multiple targets are limited by the large size of each single-chain variable fragment and compromised protein folding when several single chains are linearly assembled. Here, we describe single-domain antibody mimics that function within CAR parameters but form a very compact structure. We show that antibo

SUBMITTER: Ahn S 

PROVIDER: S-EPMC6760241 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature