Pathway-based predictive approaches for non-animal assessment of acute inhalation toxicity.

ABSTRACT: New approaches are needed to assess the effects of inhaled substances on human health. These approaches will be based on mechanisms of toxicity, an understanding of dosimetry, and the use of in silico modeling and in vitro test methods. In order to accelerate wider implementation of such approaches, development of adverse outcome pathways (AOPs) can help identify and address gaps in our understanding of relevant parameters for model input and mechanisms, and optimize non-animal approaches that can be used to investigate key events of toxicity. This paper describes the AOPs and the toolbox of in vitro and in silico models that can be used to assess the key events leading to toxicity following inhalation exposure. Because the optimal testing strategy will vary depending on the substance of i

SUBMITTER: Clippinger AJ 

PROVIDER: S-EPMC6760245 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature