An inhalation-ingestion bioaccessibility assay (IIBA) for the assessment of exposure to metal(loid)s in PM₁₀.

ABSTRACT: Although metal(loid) bioaccessibility of ambient particulate matter, with an aerodynamic diameter of <10μm (PM₁₀), has recently received increasing attention, limited research exists into standardising in-vitro methodologies using simulated lung fluid (SLF). Contradictions exist regarding which assay parameters should be adopted. Additionally, potential continuation of metal(loid) dissolution once PM₁₀ is cleared from the lungs and passed through the gastro-intestinal tract (GIT) has rarely been addressed. The objective of this study was to assess parameters that influence inhalation bioaccessibility in order to develop a conservative assay that is relevant to a human inhalation scenario. To achieve this aim, the effect of solid to liquid (S/L) ratio, extraction time,

SUBMITTER: Kastury F 

PROVIDER: S-EPMC6760254 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature