Biochemical and Functional Analysis of Cyanobacterium Geitlerinema sp. LPS on Human Monocytes.

ABSTRACT: Cyanobacterial blooms are an increasing source of environmental toxins that affect both human and animals. After ingestion of cyanobacteria, such as Geitlerinema sp., toxins and lipopolysaccharide (LPS) from this organism induce fever, gastrointestinal illness, and even death. However, little is known regarding the effects of cyanobacterial LPS on human monocytes after exposure to LPS upon ingestion. Based on our previous data using Geitlerinema sp. LPS (which was previously named Oscillatoria sp., a genus belonging to the same order as Geitlerinema), we hypothesized that Geitlerinema sp. LPS would activate human monocytes to proliferate, phagocytose particles, and produce cytokines that are critical for promoting proinflammatory responses in the gut. Our data demonstrate that Geitlerinema

SUBMITTER: Swanson-Mungerson M 

PROVIDER: S-EPMC6760288 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature