Catalytic Asymmetric Synthesis of Diketopiperazines by Intramolecular Tsuji-Trost Allylation.

ABSTRACT: We report the intramolecular Tsuji-Trost reaction of Ugi adducts to give spiro-diketopiperazines in high yield and with high enantioselectivity. This approach allows the catalytic asymmetric construction of a broad range of these medicinally important heterocycles under mild conditions, in two steps from cheap, commercially available starting materials.

SUBMITTER: Faltracco M 

PROVIDER: S-EPMC6760471 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature