Association Of GSTM1, GSTT1 And GSTP1 Polymorphisms With Breast Cancer Among Jordanian Women.

ABSTRACT:

Purpose

Genetic predisposition to disease has become one of the most investigated risk factors in recent years, and breast cancer (BC) is no exception. In this study, we investigated specific genetic variants of three candidate genes belonging to the glutathione-S-transferase superfamily that have been implicated in increased risk of cancers.

Materials and methods

This case-control study comprised 241 Jordanian women who were diagnosed with BC in addition to 219 matched controls. Gel electrophoresis of PCR products was used to visualize and genotype both the GSTM1 and GSTT1 genes, while PCR-RFLP was employed to genotype the rs1695 of the GSTP1 gene.

Results

Our findings did not reveal any correlation between the investigated polymorphisms of GST g

SUBMITTER: Al-Eitan LN 

PROVIDER: S-EPMC6760517 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature