Probiotics [LGG-BB12 or RC14-GR1] versus placebo as prophylaxis for urinary tract infection in persons with spinal cord injury [ProSCIUTTU]: a randomised controlled trial.

ABSTRACT:

Study design

Randomised double-blind factorial-design placebo-controlled trial.

Objective

Urinary tract infections (UTIs) are common in people with spinal cord injury (SCI). UTIs are increasingly difficult to treat due to emergence of multi-resistant organisms. Probiotics are efficacious in preventing UTIs in post-menopausal women. We aimed to determine whether probiotic therapy with Lactobacillus reuteri RC-14+Lactobacillus GR-1 (RC14-GR1) and/or Lactobacillus rhamnosus GG+Bifidobacterium BB-12 (LGG-BB12) are effective in preventing UTI in people with SCI.

Setting

Spinal units in New South Wales, Australia with their rural affiliations.

Methods

We recruited 207 eligible participants with SCI and stable neurogenic bladder management. They were randomised to one

SUBMITTER: Toh SL 

PROVIDER: S-EPMC6760555 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature