Genetic and metabolic predictors of hepatic fat content in a cohort of Italian children with obesity.

ABSTRACT:

Objectives

To comprehensively explore metabolic and genetic contributors to liver fat accumulation in overweight/obese children.

Methods

Two hundred thirty Italian children with obesity were investigated for metabolic parameters and genotyped for PNPLA3, TM6SF2, GCKR, and MBOAT7 gene variants. Percentage hepatic fat content (HFF%) was measured by nuclear magnetic resonance.

Results

HFF% was positively related with BMI, HOMA_IR, metabolic syndrome, ALT, AST, γGT, and albumin. Carriers of [G] allele in PNPLA3, [T] allele in GCKR and [T] allele in TM6SF2 genes had significantly higher hepatic fat content than wild-type carriers. HFF% was explained for 8.7% by metabolic and for 16.1% by genetic factors and, a model including age, gender, BMI, HOMA_IR,

SUBMITTER: Di Costanzo A 

PROVIDER: S-EPMC6760560 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature