Odor Identification Ability Predicts PET Amyloid Status and Memory Decline in Older Adults.

ABSTRACT:

Background

Odor identification deficits occur in Alzheimer's disease (AD), as measured by the 40-item University of Pennsylvania Smell Identification Test (UPSIT).

Objective

To determine if UPSIT scores predict amyloid-β (Aβ) status, determined by 11C-Pittsburgh Compound B PET. We also compared UPSIT scores to Aβ status in predicting future memory decline.

Methods

Subjects were recruited into a longitudinal clinical prediction study. We analyzed data from those who had UPSIT, cognitive testing, PIB PET, and at least 12 months' clinical follow-up. Forty-six amnestic mild cognitive impairment patients and 25 cognitively normal controls were included. Amyloid-positivity was defined as composite PIB standardized uptake value ratio >1.5. Logistic regression and Receiver Op

SUBMITTER: Kreisl WC 

PROVIDER: S-EPMC6760657 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature