Capacitative calcium entry and proliferation of human osteoblast-like MG-63 cells.

ABSTRACT:

Unlabelled

Adult bone tissue is continuously being remodelled and bone mass is maintained by a balance between osteoclastic bone resorption and osteoblastic bone formation. Alteration of osteoblastic cell proliferation may account in part for lack of balance between these two processes in bone loss of osteoporosis. There is calcium (Ca2+) control in numerous cellular functions; however, involvement of capacitative Ca2+ entry (CCE) in proliferation of bone cells is less well investigated.

Objectives

The study described here was aimed to investigate roles of CCE in the proliferation of osteoblast-like MG-63 cells.

Materials and methods

Pharmacological characterizations of CCE were undertaken in parallel, with evaluation of the expression of transient receptor potential

SUBMITTER: Labelle D 

PROVIDER: S-EPMC6760731 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature