Glomerular hyperfiltration may be a novel risk factor of restrictive spirometry pattern: Analysis of the Korea National Health and Nutrition Examination Survey (KNHANES) 2009-2015.

ABSTRACT: BACKGROUND AND OBJECTIVES:There have been limited studies regarding the association between glomerular hyperfiltration (GHF) and restrictive spirometry pattern (RSP) in Korean adults. METHODS:We used data of 23,189 adults from the Korea National Health and Nutritional Examination Survey 2009-2015 with a complete data set including spirometry, serum creatinine, and anthropometric measurements. Spirometry data included the forced expiratory volume in one second (FEV1) and forced vital capacity (FVC). We defined GHF as the >90th percentile of age & sex adjusted estimated glomerular filtration rate (eGFR), and RSP was defined as an FVC <80%-predicted value and an FEV1/FVC ratio ≥0.7. RESULTS:Participants with RSP showed higher blood pressure, fasting glucose, and triglyceride, reduced high den

SUBMITTER: Lim HI 

PROVIDER: S-EPMC6760802 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature