Quantitative magnetic resonance imaging indicates brain tissue alterations in patients after liver transplantation.

ABSTRACT:

Purpose

To investigate cerebral microstructural alterations in patients treated with calcineurin inhibitors (CNI) after orthotopic liver transplantation (OLT) using quantitative magnetic resonance imaging (qMRI) and a cross-sectional study design.

Methods

Cerebral qMRI was performed in 85 patients in a median 10 years after OLT compared to 31 healthy controls. Patients were treated with different dosages of CNI or with a CNI-free immunosuppression (CNI-free: n = 19; CNI-low: n = 36; CNI-standard: n = 30). T2-, T2*- and T2'- relaxation times, as well as apparent diffusion coefficient (ADC) and fractional anisotropy (FA) were measured in brain gray and white matter by using the regions of interest method.

Results

In comparison to controls, patients revealed significantl

SUBMITTER: Goede LL 

PROVIDER: S-EPMC6760889 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature