Genes lost during the transition from land to water in cetaceans highlight genomic changes associated with aquatic adaptations.

ABSTRACT: The transition from land to water in whales and dolphins (cetaceans) was accompanied by remarkable adaptations. To reveal genomic changes that occurred during this transition, we screened for protein-coding genes that were inactivated in the ancestral cetacean lineage. We found 85 gene losses. Some of these were likely beneficial for cetaceans, for example, by reducing the risk of thrombus formation during diving (F12 and KLKB1), erroneous DNA damage repair (POLM), and oxidative stress-induced lung inflammation (MAP3K19). Additional gene losses may reflect other diving-related adaptations, such as enhanced vasoconstriction during the diving response (mediated by SLC6A18) and altered pulmonary surfactant composition (SEC14L3), while loss of SLC4A

SUBMITTER: Huelsmann M 

PROVIDER: S-EPMC6760925 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature