Polyphenol-based nanoplatform for MRI/PET dual-modality imaging guided effective combination chemotherapy.

ABSTRACT: Combination therapy with multiple chemotherapeutic agents is the main approach for cancer treatment in the clinic. Polyphenol-based materials are found in our diet, demonstrate good biocompatibility, and prevent numerous diseases. In this study, we encapsulate two drugs in a single polyphenol-based polymer with Fe³⁺ or Mn²⁺ ions as the cross-linker for cancer therapy. The combination index of two drugs is an essential parameter to evaluate drug combinations. The amphiphilic polymer poly(ethylene glycol)-block-polydopamine (PEG-PDA) was prepared by RAFT polymerization. The nanoparticles were prepared via self-assembly with Fe³⁺ or Mn²⁺ ions. Both doxorubicin (DOX) and simvastatin (SV) were encapsulated in the core of the nanoparticles. The cell vi

SUBMITTER: Wang J 

PROVIDER: S-EPMC6760993 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature