Mechanism of Enhanced MerTK-Dependent Macrophage Efferocytosis by Extracellular Vesicles.

ABSTRACT:

Objective

Extracellular vesicles secreted by cardiosphere-derived cells (CDC_ev) polarize macrophages toward a distinctive phenotype with enhanced phagocytic capacity (M_CDCev). These changes underlie cardioprotection by CDC_ev and by the parent CDCs, notably attenuating the no-reflow phenomenon following myocardial infarction, but the mechanisms are unclear. Here, we tested the hypothesis that M_CDCev are especially effective at scavenging debris from dying cells (ie, efferocytosis) to attenuate irreversible damage post-myocardial infarction. Approach and Results: In vitro efferocytosis assays with bone marrow-derived macrophages, and in vivo transgenic rodent models of myocardial infarction, demonstrate enhanced apoptotic cell clearance wit

SUBMITTER: de Couto G 

PROVIDER: S-EPMC6760997 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature