Regulation of Stress Granule Formation by Inflammation, Vascular Injury, and Atherosclerosis.

ABSTRACT:

Objective

Stress granules (SGs) are dynamic cytoplasmic aggregates containing mRNA, RNA-binding proteins, and translation factors that form in response to cellular stress. SGs have been shown to contribute to the pathogenesis of several human diseases, but their role in vascular diseases is unknown. This study shows that SGs accumulate in vascular smooth muscle cells (VSMCs) and macrophages during atherosclerosis. Approach and Results: Immunohistochemical analysis of atherosclerotic plaques from LDLR^-/- mice revealed an increase in the stress granule-specific markers Ras-G3BP1 (GTPase-activating protein SH3 domain-binding protein) and PABP (poly-A-binding protein) in intimal macrophages and smooth muscle cells that correlated with disease progression. In vitro

SUBMITTER: Herman AB 

PROVIDER: S-EPMC6761003 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature