Enhanced In Vivo Delivery of Stem Cells using Microporous Annealed Particle Scaffolds.

ABSTRACT: Delivery to the proper tissue compartment is a major obstacle hampering the potential of cellular therapeutics for medical conditions. Delivery of cells within biomaterials may improve localization, but traditional and newer void-forming hydrogels must be made in advance with cells being added into the scaffold during the manufacturing process. Injectable, in situ cross-linking microporous scaffolds are recently developed that demonstrate a remarkable ability to provide a matrix for cellular proliferation and growth in vitro in three dimensions. The ability of these scaffolds to deliver cells in vivo is currently unknown. Herein, it is shown that mesenchymal stem cells (MSCs) can be co-injected locally with microparticle scaffolds assembled in situ immediately following injection. MSC deli

SUBMITTER: Koh J 

PROVIDER: S-EPMC6761037 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature